An attempt was made to evaluate differences in Mg and other related electrolytes (CaNa, and K) status in patients` with primary hypertension and patients on diuretic drug therapy.
The subjects consisted of 24 normotensive controls (group I), 12 essential hypertensive patients (group 1), 16 hypertensive patients on diuretic drug therapy less than 6 ´months (group I1), and 27 hypertensive patients on-.diuretic drug-therapy more than 6 months (group 1Y).
Dietary intakes of Mg and other electrolytes and their distribution in blood and urinary excretion were measured.
The results were summarized as follows:
(1) Dietary intakes of Mg and other electrolytes (Ca, Na and K) were not significantly different among 4 groups.
(2) The plasma Mg and Na concentration in essential hypertensive: patients were significantly lower (p<.05, p<.0l, respectively) but whole blood K and urinary Mg excretion were significantly higher (p<. 01, p<. 05, respectively) than those of normotensive controls.
There was possibility that low plasma Mg in essential hypertensive patients was partly due to increased urinary Mg for the group.
(3) In hypertensive patients on diuretic drug therapy less than 6 months,´ whole blood K concentration was significantly lower (p<01) than that of essential hypertensive patients. _
This result suggested that decrease in blood pressure with short term diuretic drug therapy was associated with lower whole blood K.
(4) In hypertensive patients on diuretic drug therapy more than 6 months, plasma Mg and Na concentration were significantly higher than those of essential hypertensive
patients.
It showed that decrease in blood pressure with long-term diuretic drug therapy was associated with increased plasma Mg and Na concentration to the level of normotensive controls.
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